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Following a novel analgesic from target ID to clinical trials
Only 2% of novel analgesics will make it through clinical development. Understanding the development process for an individual pain...
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- Aug 13, 2022
- 1 min
Complex 3D human model systems to bridge the translation gap in pain.
Key differences in pain mechanisms between preclinical species and humans have hindered the development of new analgesics. Recent...
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- Aug 8, 2022
- 2 min
New study highlights need for female-focused research
A newly published article "RNA profiling of human dorsal root ganglia reveals sex-differences in mechanisms promoting neuropathic pain"...
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- Mar 9, 2021
- 3 min
Vertex unlikely to repeat their CF success in Pain as they lack a personalized analgesics® approach.
Vertex are looking to other therapeutic areas to repeat their undoubted success in Cystic Fibrosis and create a sustainable pipeline....
267 views0 comments
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- Sep 4, 2020
- 1 min
How to improve innovation in analgesic development: Poster presented at IASP virtual Meeting 2020.
Increasing innovation within analgesic R&D is key to identify new treatment options for millions of pain patients. I am delighted...
199 views0 comments
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- Aug 26, 2020
- 1 min
Peripherally acting phase 1 pain drug acquired in $940Million deal.
Yesterday (25th Aug 2020) saw the announcement that ACADIA Pharmaceuticals acquires privately held Dallas, TX-based CerSci Therapeutics,...
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- Aug 18, 2020
- 2 min
Unity Bio's novel pain drug fails in OA. Did they miss out by not using a precision approach?
"Unity Biotechnology announced the 12-week results from the Phase 2 study of UBX0101, a p53/MDM2 interaction inhibitor, in patients with...
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- Aug 11, 2020
- 2 min
FDA approves Trevena’s Mu opioid for Acute pain.
Back in January 2020 the FDA had a number of expert panels voting on opioid drugs – ultimately giving negative feedback for the class. So...
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- Aug 7, 2020
- 2 min
NICE guidance on chronic pain could prevent patients receiving life altering treatments
Nice guidance on chronic pain creates wrong messages and potentially stops patients receiving life altering medication. This week NICE...
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- Jul 7, 2020
- 2 min
P2X3 cough drug: Negative Ph II = 70% loss of stock price but severe patient group may show the way.
Targeting the right patient population in clinical trials is key to avoiding a false negative and giving a medicine the best chance of...
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- May 26, 2020
- 3 min
Biogen ready to write-off Nav1.7 assets in pain?
The last annual report for Biogen indicates worrying signs for the future development of the latest stage Nav1.7 compound Vixotrigine.
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- May 12, 2020
- 1 min
Revolutionising pain R&D by developing Precision Analgesics
Presentation by Mark J. Field at SMI Pain Therapeutics Meeting 12th May 2020. You can find a copy of the presentation above. It covers...
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- Apr 20, 2020
- 4 min
COVID19: creating a new era for 'Citizen Science'
"Citizen science" is defined as "scientific work undertaken by members of the general public, often in collaboration with or under the...
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- Mar 20, 2020
- 2 min
P2X3 receptor antagonists pass Phase 3 trials for cough – potential also in pain?
P2X3 receptor channels are attractive therapeutic targets as they are expressed in sensory neurons, activated by extracellular ATP and...
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- Mar 17, 2020
- 2 min
Which companies are interested in Pain? The useful analytics below LinkedIn likes & comments.
I believe LinkedIn is a great source for keeping up to date with content which can be tailored to be most relevant to you. Over the past...
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- Feb 21, 2020
- 3 min
Is this still a relevant target for new pain treatments: the α2δ (Alpha2Delta) Ca2+ channel?
The traditional approach to analgesic development could be described as 'exceptionally challenging', with a clinical success rate of...
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- Feb 10, 2020
- 4 min
Has a new study found a personalized approach for Nav1.7? 'Precision Analgesics' may be a better bet
The difficulties of pain research are highlighted well by the tale of the Nav1.7 sodium channel, which was thought to be the ‘holy grail’...
81 views0 comments
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- Feb 6, 2020
- 3 min
So Pfizer & Lilly do ask FDA to approve Tanezumab for OA pain...
Just a few months ago some commentators had pronounced the death of Tanezumab and the whole anti-NGF class it leads, following years of...
325 views0 comments
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- Feb 3, 2020
- 2 min
Vertex discontinues development of its Nav1.8 pain drug VX-961.
Deep within the Full-Year and Fourth-Quarter 2019 Financial Results for Vertex you can find this statement: “Pain: The company announced...
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- Jan 29, 2020
- 2 min
Big data & human biomarkers – the era of citizen scientists
The probability of a new analgesic making it through clinical development is 2%. Five-times lower than other therapeutic areas. This...
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